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Home > Industry News

Heart-on-a-chip Model could Replicate Myocardial Infarction

Views : 90
Update time : 2022-12-27 13:47:50
        Researchers in the USC Department of Biomedical Engineering have developed a "heart-on-a-chip" model, a device that could one day serve as a test bed for developing new heart drugs and even personalized drugs. The research was published recently in the journal Science Advances.
        The researchers say the device replicates some of the key features of a heart attack in a relatively easy-to-use system, which allows them to better understand what happens to the heart after the onset of the attack, so they can develop and test the most effective drugs to limit the degeneration of heart tissue caused by the onset of the attack.
        Heart attacks result when fat, cholesterol and other substances in the coronary arteries severely impede the flow of oxygen-rich blood to the heart. However, scientists do not fully understand this process, especially how cells in healthy and injured parts of the heart "communicate" with each other and how and why they change after a heart attack. The researchers believe the "heart-on-a-chip" model could unravel these mysteries.
        At the bottom of the model is a 22 x 22 mm square microfluidic device made of a rubber-like polymer called PDMS, with two channels on opposite sides through which gas flows. On top is a very thin layer of the same rubber material, which is permeable to oxygen. A layer of protein is then molded into the top of the chip to align the heart cells and form the same structure as a human heart, and then the rodent heart cells are allowed to grow on the protein.
 
To simulate a heart attack, oxygenated and non-oxygenated gases are released through each channel of the microfluidic device. The microfluidic devices are small, clear and easily visible under a microscope, thus allowing researchers to observe in real time the functional changes that occur in the heart after an attack, including arrhythmias/arrhythmias and systolic dysfunction.
 
In contrast, animal models do not allow researchers to make such real-time observations. In addition, traditional cell culture models expose heart cells to high, medium or low levels of oxygen in a uniform rather than graded manner, meaning they do not mimic the reality of damaged heart cells in the so-called border zone after a heart attack.
 
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